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The influence of land use patterns on stream water quality is scale-dependent in space and time. Understanding the relationship between landscape characteristics and water quality is of great importance to improve water contamination prediction in unmonitored watersheds and for providing guidelines for watershed land use planning. In this study, five water sampling sites in the upper Dan River basin were established to monitor seasonal water chemical contamination over the period of 2000 to 2008. The relationships between land use patterns and water quality were analyzed across multiple-scales using redundancy analysis. The results showed that stream water quality variables displayed highly temporal variations, with electrical conductivity (EC), ammonium nitrogen (NH₄⁺-N), nitrate nitrogen (NO₃⁻ N), and total suspended solids (TSS) all generally displaying higher levels in the wet season, while there …